Chemicals and Drugs

Ibogaine

One of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.

Chemical Identity

Chemical Information

Molecular Formula
C20H26N2O
Molecular Weight
310.4 g/mol
CAS Registry No.
83-74-9
IUPAC Name
(1R,15R,17S,18S)-17-ethyl-7-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene
InChIKey
HSIBGVUMFOSJPD-CFDPKNGZSA-N
SMILES
CC[C@H]1C[C@@H]2C[C@@H]3[C@H]1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC
MeSH Unique ID
D007050
Source
PubChem CID 197060

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 12-Methoxyibogamine
  • 12 Methoxyibogamine
  • Endabuse
  • NIH-10567
  • NIH 10567
  • NIH10567

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(76); was see under ALKALOIDS 1976-90

MeSH Record

Previous Indexing

  • Alkaloids (1969-1975)
  • Azepines (1975)
  • Benzazepines (1969-1974)
  • Indoles (1972-1975)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.436w.681.444w
  2. D03w.633.100.473.390w
  3. D03w.633.100.473.402w.681.444w
  4. D03w.633.100.496.500.500w.681.444w

AMA Style

References

  1. National Library of Medicine. Ibogaine. Medical Subject Headings (MeSH). 2026. Unique ID D007050. http://id.nlm.nih.gov/mesh/2026/D007050
  2. Ibogaine. In: Wikipedia. https://en.wikipedia.org/wiki/Ibogaine
  3. Ibogaine. In: Wikidata. https://www.wikidata.org/wiki/Q409455
  4. Ibogaine. In: PubChem Compound. CID 197060. https://pubchem.ncbi.nlm.nih.gov/compound/197060