Chemicals and Drugs

Imipenem Drug Combination Cilastatin

Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.

Chemical Identity

Chemical Information

Molecular Formula
C28H45N5O10S2
Molecular Weight
675.8 g/mol
IUPAC Name
(Z)-7-[(2S)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;hydrate
InChIKey
DAYDLKPFBFPKHL-MYZPLXEGSA-N
SMILES
C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.CC1(C[C@@H]1C(=O)N/C(=C\CCCCSC[C@H](C(=O)O)N)/C(=O)O)C.O
MeSH Unique ID
D000077728
Source
PubChem CID 11954222

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • Cilastatin, Imipenem Drug Combination
  • Imipenem - Cilastatin
  • Imipenem Cilastatin
  • Imipenem-Cilastatin
  • Cilastatin, Imipenem
  • Imipenem - Cilastatin Sodium
  • Imipenem Cilastatin Sodium
  • Imipenem-Cilastatin Sodium
  • Imipenem-Cilastatin, Sodium Salt
  • MK 0787-MK 0791 mixture
  • MK 787-MK 791 mixture
  • Primaxin
  • Thienam
  • Tienam 500
  • Zienam
  • Imipenem Cilastatin, Sodium Salt
  • MK 0787 MK 0791 mixture
  • MK 787 MK 791 mixture

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1985)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.589w.099w.124w.300.500.500w
  2. D02w.455w.426w.392.368w.533w.200w.500w
  3. D03w.633.100.300w.124w.300.500.500w
  4. D10w.251w.355w.325w.200w.500w
  5. D26.310w.356w

AMA Style

References

  1. National Library of Medicine. Imipenem Drug Combination Cilastatin. Medical Subject Headings (MeSH). 2026. Unique ID D000077728. http://id.nlm.nih.gov/mesh/2026/D000077728
  2. Imipenem Drug Combination Cilastatin. In: Wikipedia. https://en.wikipedia.org/wiki/Imipenem/cilastatin
  3. Imipenem Drug Combination Cilastatin. In: Wikidata. https://www.wikidata.org/wiki/Q6004128
  4. Imipenem Drug Combination Cilastatin. In: PubChem Compound. CID 11954222. https://pubchem.ncbi.nlm.nih.gov/compound/11954222