Chemicals and Drugs

Immunoglobulin alpha-Chains

The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • Ig alpha Chains
  • Immunoglobulin alpha-Chain
  • Immunoglobulins, alpha-Chain
  • alpha-Chain Immunoglobulins
  • alpha-Immunoglobulin Heavy Chain
  • alpha-Immunoglobulin Heavy Chains
  • Chains, Ig alpha
  • Heavy Chain, alpha-Immunoglobulin
  • Heavy Chains, alpha-Immunoglobulin
  • Immunoglobulin alpha Chain
  • Immunoglobulin alpha Chains
  • Immunoglobulins, alpha Chain
  • alpha Chain Immunoglobulins
  • alpha Chains, Ig
  • alpha Immunoglobulin Heavy Chain
  • alpha Immunoglobulin Heavy Chains
  • alpha-Chain, Immunoglobulin
  • alpha-Chains, Immunoglobulin

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

gammopathy: coordinate IMMUNOGLOBULIN ALPHA-CHAINS (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA (IM) or ALPHA-CHAIN DISEASE (IM), follow text; DF: IG ALPHA CHAIN

MeSH Record

History Note

2006 (1976)

MeSH Record

Previous Indexing

  • IgA (1973-1975)
  • Immunoglobulin Fragments (1973-1975)
  • Immunoglobulins, Heavy Chain (1975)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.619w.026w.515
  2. D12.776w.124w.486.485.705.500w.350
  3. D12.776w.124w.790.651.114w.619w.026w.515
  4. D12.776w.124w.790.651.705.500w.350
  5. D12.776w.377w.715.548.114w.619w.026w.515
  6. D12.776w.377w.715.548.705.500w.350

AMA Style

References

  1. National Library of Medicine. Immunoglobulin alpha-Chains. Medical Subject Headings (MeSH). 2026. Unique ID D007137. http://id.nlm.nih.gov/mesh/2026/D007137
  2. Immunoglobulin alpha-Chains. In: Wikidata. https://www.wikidata.org/wiki/Q76876909