Chemicals and Drugs

Immunoglobulin gamma-Chains

Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • Immunoglobulin gamma-Chain
  • Immunoglobulins, gamma-Chain
  • gamma Immunoglobulin Heavy Chain
  • gamma Immunoglobulin Heavy Chains
  • gamma-Chain Immunoglobulins
  • Immunoglobulin gamma Chain
  • Immunoglobulin gamma Chains
  • Immunoglobulins, gamma Chain
  • gamma Chain Immunoglobulins
  • gamma-Chain, Immunoglobulin
  • gamma-Chains, Immunoglobulin
  • gamma-1-Immunoglobulin Heavy Chain
  • gamma-2a-Immunoglobulin Heavy Chain
  • gamma-2b-Immunoglobulin Heavy Chain
  • Heavy Chain, gamma-1-Immunoglobulin
  • Heavy Chain, gamma-2a-Immunoglobulin
  • Heavy Chain, gamma-2b-Immunoglobulin
  • gamma 1 Immunoglobulin Heavy Chain
  • gamma 2a Immunoglobulin Heavy Chain
  • gamma 2b Immunoglobulin Heavy Chain

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

gammopathy: coordinate IMMUNOGLOBULIN GAMMA-CHAINS (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA (IM) or HEAVY CHAIN DISEASE (IM), follow text; DF: IG GAMMA CHAIN

MeSH Record

History Note

2006 (1976)

MeSH Record

Previous Indexing

  • IgG (1973-1975)
  • Immunoglobulin Fragments (1973-1975)
  • Immunoglobulins, Heavy Chain (1975)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.619w.393w.522
  2. D12.776w.124w.486.485.705.500w.380
  3. D12.776w.124w.790.651.114w.619w.393w.522
  4. D12.776w.124w.790.651.705.500w.380
  5. D12.776w.377w.715.548.114w.619w.393w.522
  6. D12.776w.377w.715.548.705.500w.380

AMA Style

References

  1. National Library of Medicine. Immunoglobulin gamma-Chains. Medical Subject Headings (MeSH). 2026. Unique ID D007142. http://id.nlm.nih.gov/mesh/2026/D007142
  2. Immunoglobulin gamma-Chains. In: Wikidata. https://www.wikidata.org/wiki/Q76741921