Phenomena and Processes

Immunoreceptor Tyrosine-Based Activation Motif

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

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Synonyms

5 entry terms
  • Immune Receptor Tyrosine-Based Activation Motif
  • Immuno-Receptor Tyrosine-Based Activation Motif
  • Immune Receptor Tyrosine Based Activation Motif
  • Immuno Receptor Tyrosine Based Activation Motif
  • Immunoreceptor Tyrosine Based Activation Motif

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2013

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.500.440w

AMA Style

References

  1. National Library of Medicine. Immunoreceptor Tyrosine-Based Activation Motif. Medical Subject Headings (MeSH). 2026. Unique ID D061625. http://id.nlm.nih.gov/mesh/2026/D061625
  2. Immunoreceptor Tyrosine-Based Activation Motif. In: Wikipedia. https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_activation_motif
  3. Immunoreceptor Tyrosine-Based Activation Motif. In: Wikidata. https://www.wikidata.org/wiki/Q6005558