Chemicals and Drugs

Immunosuppressive Agents

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

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Classification

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MeSH Record

Synonyms

5 entry terms
  • Immunosuppressant
  • Immunosuppressants
  • Immunosuppressive Agent
  • Agent, Immunosuppressive
  • Agents, Immunosuppressive

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

66(64)

MeSH Hierarchy

Tree Number

MeSH Record

NLM Classification

QW 955

AMA Style

References

  1. National Library of Medicine. Immunosuppressive Agents. Medical Subject Headings (MeSH). 2026. Unique ID D007166. http://id.nlm.nih.gov/mesh/2026/D007166
  2. Immunosuppressive Agents. In: Wikipedia. https://en.wikipedia.org/wiki/Immunosuppressive_drug
  3. Immunosuppressive Agents. In: Wikidata. https://www.wikidata.org/wiki/Q249619