Organisms

Inbred CFTR Mice

A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.

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Synonyms

9 entry terms
  • Mice, CFTR
  • Mice, Inbred CFTR
  • Mouse, CFTR
  • Mouse, Inbred CFTR
  • CFTR Mice
  • CFTR Mice, Inbred
  • CFTR Mouse
  • CFTR Mouse, Inbred
  • Inbred CFTR Mouse

MeSH Record

Aspects Covered

18 allowable subheadings

Indexed with the subheadings abnormalities, anatomy & histology, blood, cerebrospinal fluid, classification, embryology, genetics, growth & development, immunology, injuries, metabolism, microbiology, parasitology, physiology, psychology, surgery, urine, virology.

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Indexing Annotation

NIM with no qualifiers when experimental animal

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History Note

94

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Previous Indexing

  • Mice (1992-1993)

MeSH Hierarchy

Tree Numbers

  1. B01w.050w.050.199w.520w.520.445
  2. B01w.050w.150w.900w.649w.313w.992w.635w.505w.500w.400.445

AMA Style

References

  1. National Library of Medicine. Inbred CFTR Mice. Medical Subject Headings (MeSH). 2026. Unique ID D018181. http://id.nlm.nih.gov/mesh/2026/D018181
  2. Inbred CFTR Mice. In: Wikidata. https://www.wikidata.org/wiki/Q68806508