Organisms

Inbred mdx Mice

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • Mice, Inbred mdx
  • Mice, mdx
  • Mouse, Inbred mdx
  • Mouse, mdx
  • Inbred mdx Mouse
  • mdx Mice
  • mdx Mouse

MeSH Record

Aspects Covered

18 allowable subheadings

Indexed with the subheadings abnormalities, anatomy & histology, blood, cerebrospinal fluid, classification, embryology, genetics, growth & development, immunology, injuries, metabolism, microbiology, parasitology, physiology, psychology, surgery, urine, virology.

MeSH Record

Indexing Annotation

NIM with no qualifiers when experimental animal

MeSH Record

History Note

94

MeSH Record

Previous Indexing

  • Mice, Inbred C57BL (1984-1993)
  • Mice, Mutant Strains (1984-1993)

MeSH Hierarchy

Tree Numbers

  1. B01w.050w.050.199w.520w.520.420w.500
  2. B01w.050w.150w.900w.649w.313w.992w.635w.505w.500w.400.420w.500
  3. B01w.050w.150w.900w.649w.313w.992w.635w.505w.500w.550.265

AMA Style

References

  1. National Library of Medicine. Inbred mdx Mice. Medical Subject Headings (MeSH). 2026. Unique ID D018101. http://id.nlm.nih.gov/mesh/2026/D018101
  2. Inbred mdx Mice. In: Wikidata. https://www.wikidata.org/wiki/Q69466189