Chemicals and Drugs

Indomethacin

A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.

Chemical Identity

Chemical Information

Molecular Formula
C19H16ClNO4
Molecular Weight
357.8 g/mol
CAS Registry No.
53-86-1
IUPAC Name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
InChIKey
CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
MeSH Unique ID
D007213
Source
PubChem CID 3715

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • Indometacin
  • Amuno
  • Indocid
  • Indocin
  • Indomet 140
  • Indomethacin Hydrochloride
  • Metindol
  • Osmosin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1966 (1964)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.473.420w

MeSH Record

NLM Classification

QV 95

AMA Style

References

  1. National Library of Medicine. Indomethacin. Medical Subject Headings (MeSH). 2026. Unique ID D007213. http://id.nlm.nih.gov/mesh/2026/D007213
  2. Indomethacin. In: Wikipedia. https://en.wikipedia.org/wiki/Indometacin
  3. Indomethacin. In: Wikidata. https://www.wikidata.org/wiki/Q409231
  4. Indomethacin. In: PubChem Compound. CID 3715. https://pubchem.ncbi.nlm.nih.gov/compound/3715