Chemicals and Drugs

Inhibitor of Growth Protein 1

A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Reduced expression and chromosomal rearrangements of the ING1 gene are associated with different cancers including HEAD AND NECK NEOPLASMS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Reduced expression and chromosomal rearrangements of the ING1 gene are associated with different cancers including HEAD AND NECK NEOPLASMS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • ING-1 Protein
  • ING1 Protein
  • p33ING Protein
  • ING 1 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Intracellular Signaling Peptides and Proteins (2005-2017)
  • Nuclear Proteins (2005-2017)
  • Tumor Suppressor Proteins (2005-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.368
  2. D12.776w.476.383
  3. D12.776w.624.776.503
  4. D12.776w.660w.494

AMA Style

References

  1. National Library of Medicine. Inhibitor of Growth Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D000076023. http://id.nlm.nih.gov/mesh/2026/D000076023
  2. Inhibitor of Growth Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q24777363