Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Inhibitory Concentration 50

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

2 entry terms
  • IC50
  • Concentration 50, Inhibitory

MeSH Record

Indexing Annotation

do not confuse with LETHAL DOSE 50, determined in animals

MeSH Record

History Note

1999

MeSH Record

Previous Indexing

  • Cell Survival/drug effects (1971-1998)

MeSH Hierarchy

Tree Numbers

  1. E05.940w.350w
  2. G07.690.936.563w

AMA Style

References

  1. National Library of Medicine. Inhibitory Concentration 50. Medical Subject Headings (MeSH). 2026. Unique ID D020128. http://id.nlm.nih.gov/mesh/2026/D020128
  2. Inhibitory Concentration 50. In: Wikipedia. https://en.wikipedia.org/wiki/IC50
  3. Inhibitory Concentration 50. In: Wikidata. https://www.wikidata.org/wiki/Q286779