Diseases

Injection Site Reaction

Adverse reactions that occur initially at the site of injection or infusion. Milder type is confined to a local allergic flare reaction. A more severe reaction is caused by extravasation of VESICANTS from the blood vessel at the site of injection and can cause damage to the surrounding tissue. In tumor flare reaction symptoms involve well beyond the injection site such as an increase in the tumor size and tumor markers levels, bone pain, and HYPERCALCEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Adverse reactions that occur initially at the site of injection or infusion. Milder type is confined to a local allergic flare reaction. A more severe reaction is caused by extravasation of VESICANTS from the blood vessel at the site of injection and can cause damage to the surrounding tissue. In tumor flare reaction symptoms involve well beyond the injection site such as an increase in the tumor size and tumor markers levels, bone pain, and HYPERCALCEMIA.

MeSH Record

Classification

Related Concepts

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MeSH Record

Synonyms

8 entry terms
  • Injection Site Adverse Event
  • Injection Site Event
  • Injection Site Events
  • Injection Site Reactions
  • Infusion Site Adverse Event
  • Infusion Site Adverse Reaction
  • Infusion Site Reaction
  • Infusion Site Reactions

MeSH Record

Aspects Covered

32 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Drug-Related Side Effects and Adverse Reactions (1969-2017)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Injection Site Reaction. Medical Subject Headings (MeSH). 2026. Unique ID D000075662. http://id.nlm.nih.gov/mesh/2026/D000075662
  2. Injection Site Reaction. In: Wikipedia. https://en.wikipedia.org/wiki/Injection_site_reaction
  3. Injection Site Reaction. In: Wikidata. https://www.wikidata.org/wiki/Q6034307