Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Insertional Mutagenesis

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

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Classification

Broader headings

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Synonyms

25 entry terms
  • Mutagenesis, Insertional
  • Gene Insertion
  • Insertion Mutation
  • Insertional Activation
  • Linker-Insertion Mutagenesis
  • Mutagenesis, Cassette
  • Sequence Insertion
  • Viral Insertional Mutagenesis
  • Activation, Insertional
  • Activations, Insertional
  • Cassette Mutagenesis
  • Gene Insertions
  • Insertion Mutations
  • Insertion, Gene
  • Insertion, Sequence
  • Insertional Activations
  • Insertional Mutagenesis, Viral
  • Insertions, Gene
  • Insertions, Sequence
  • Linker Insertion Mutagenesis
  • Mutagenesis, Linker-Insertion
  • Mutagenesis, Viral Insertional
  • Mutation, Insertion
  • Mutations, Insertion
  • Sequence Insertions

MeSH Record

Aspects Covered

11 allowable subheadings

Indexed with the subheadings drug effects, economics, genetics, history, immunology, instrumentation, methods, physiology, radiation effects, standards, statistics & numerical data.

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History Note

91

MeSH Record

Previous Indexing

  • DNA Insertion Elements (1983-1990)
  • Mutation (1982-1990)

MeSH Hierarchy

Tree Numbers

  1. E05.393.420w.601w.550w
  2. G05.365w.590w.575w
  3. G05.558w.550w

MeSH Record

NLM Classification

QU 55.95

AMA Style

References

  1. National Library of Medicine. Insertional Mutagenesis. Medical Subject Headings (MeSH). 2026. Unique ID D016254. http://id.nlm.nih.gov/mesh/2026/D016254
  2. Insertional Mutagenesis. In: Wikipedia. https://en.wikipedia.org/wiki/Insertional_mutagenesis
  3. Insertional Mutagenesis. In: Wikidata. https://www.wikidata.org/wiki/Q1967554