Chemicals and Drugs

Insulin-Like Growth Factor Binding Protein 1

One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • IGF-Binding Protein 1
  • IGFBP-1
  • IGF Binding Protein 1
  • Insulin Like Growth Factor Binding Protein 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2005(1992)

MeSH Record

Previous Indexing

  • Carrier Proteins (1992-1995)

MeSH Hierarchy

Tree Number

  1. D12.776w.157w.420w.250

AMA Style

References

  1. National Library of Medicine. Insulin-Like Growth Factor Binding Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D018970. http://id.nlm.nih.gov/mesh/2026/D018970
  2. Insulin-Like Growth Factor Binding Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q24771865