Chemicals and Drugs

Insulin Receptor Substrate Proteins

A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

17 entry terms
  • IRS Signaling Adaptor Proteins
  • Insulin Receptor Substrate-1
  • Insulin Receptor Substrate-1 Protein
  • Insulin Receptor Substrate-2
  • Insulin Receptor Substrate-2 Protein
  • Insulin Receptor Substrate-3
  • Insulin Receptor Substrate-3 Protein
  • Insulin Receptor Substrate-4
  • Insulin Receptor Substrate-4 Protein
  • Insulin Receptor Substrate 1
  • Insulin Receptor Substrate 1 Protein
  • Insulin Receptor Substrate 2
  • Insulin Receptor Substrate 2 Protein
  • Insulin Receptor Substrate 3
  • Insulin Receptor Substrate 3 Protein
  • Insulin Receptor Substrate 4
  • Insulin Receptor Substrate 4 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2009(1992)

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (2008)
  • Phosphoproteins (1992-2008)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.301w
  2. D12.776w.157w.057w.045w
  3. D12.776w.476.024w.382w

AMA Style

References

  1. National Library of Medicine. Insulin Receptor Substrate Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D055504. http://id.nlm.nih.gov/mesh/2026/D055504
  2. Insulin Receptor Substrate Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Insulin_receptor_substrate
  3. Insulin Receptor Substrate Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q101433828