Structured Summary
Abstract
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
8 entry terms
- Insulin Protease
- Insulin Proteinase
- Insulin-Degrading Enzyme
- Insulinase
- Enzyme, Insulin-Degrading
- Insulin Degrading Enzyme
- Protease, Insulin
- Proteinase, Insulin
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
97; was INSULINASE 1963-96 (see under PEPTIDE HYDROLASES 1975-90, see under ENDOPEPTIDASES 1963-74)
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References
- National Library of Medicine. Insulysin. Medical Subject Headings (MeSH). 2026. Unique ID D007339. http://id.nlm.nih.gov/mesh/2026/D007339
- Insulysin. In: Wikipedia. https://en.wikipedia.org/wiki/Insulysin
- Insulysin. In: Wikidata. https://www.wikidata.org/wiki/Q3799253