Chemicals and Drugs

Interleukin-18

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

11 entry terms
  • IFN-gamma Inducing Factor
  • IFN-gamma-Inducing Factor
  • IL-18
  • IL18
  • Interferon-gamma Inducing Factor
  • Interferon-gamma-Inducing Factor
  • IFN gamma Inducing Factor
  • Inducing Factor, IFN-gamma
  • Inducing Factor, Interferon-gamma
  • Interferon gamma Inducing Factor
  • Interleukin 18

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1999; use INTERLEUKIN-18 (NM) 1995-1998

MeSH Record

Previous Indexing

  • Cytokines (1995-1998)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Interleukin-18. Medical Subject Headings (MeSH). 2026. Unique ID D020382. http://id.nlm.nih.gov/mesh/2026/D020382
  2. Interleukin-18. In: Wikidata. https://www.wikidata.org/wiki/Q24773646