Structured Summary
Abstract
A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.
Chemical Identity
Chemical Information
- Molecular Formula
- C25H28N6O
- Molecular Weight
- 428.5 g/mol
- CAS Registry No.
- 138402-11-6
- IUPAC Name
- 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
- InChIKey
- YOSHYTLCDANDAN-UHFFFAOYSA-N
- SMILES
- CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5
- MeSH Unique ID
- D000077405
- Source
- PubChem CID 3749
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
Drug Class
Pharmacological Action
MeSH Record
Synonyms
9 entry terms
- 2-N-Butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one
- Aprovel
- Avapro
- BMS 186295
- BMS-186295
- Karvea
- SR 47436
- SR-47436
- SR47436
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1993)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Irbesartan. Medical Subject Headings (MeSH). 2026. Unique ID D000077405. http://id.nlm.nih.gov/mesh/2026/D000077405
- Irbesartan. In: Wikipedia. https://en.wikipedia.org/wiki/Irbesartan
- Irbesartan. In: Wikidata. https://www.wikidata.org/wiki/Q947266
- Irbesartan. In: PubChem Compound. CID 3749. https://pubchem.ncbi.nlm.nih.gov/compound/3749