Diseases

Isaacs Syndrome

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

20 entry terms
  • Continuous Muscle Activity Syndrome
  • Gamstorp-Wohlfart Syndrome
  • Isaacs' Syndrome
  • Isaacs-Mertens Syndrome
  • Myokymia, Continuous
  • Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis
  • Neuromyotonia
  • Pseudomyotonia Syndrome of Isaacs
  • Quantal Squander
  • Syndrome of Continuous Muscle Activity
  • Continuous Myokymia
  • Continuous Myokymias
  • Gamstorp Wohlfart Syndrome
  • Isaac Syndrome
  • Isaacs Mertens Syndrome
  • Isaacs Pseudomyotonia Syndrome
  • Myokymias, Continuous
  • Acquired Neuromyotonia
  • Pseudomyotonia
  • Neuromyotonia, Acquired

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2000; for ISAACS' SYNDROME use FASCICULATION 1995-1999

MeSH Record

Previous Indexing

  • Fasciculation (1995-1999)

MeSH Hierarchy

Tree Numbers

  1. C05w.651w.392w
  2. C10w.668w.829w.425w

AMA Style

References

  1. National Library of Medicine. Isaacs Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D020386. http://id.nlm.nih.gov/mesh/2026/D020386
  2. Isaacs Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Neuromyotonia
  3. Isaacs Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q520797