Chemicals and Drugs

Isradipine

A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.

Chemical Identity

Chemical Information

Molecular Formula
C19H21N3O5
Molecular Weight
371.4 g/mol
CAS Registry No.
75695-93-1
IUPAC Name
3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey
HMJIYCCIJYRONP-UHFFFAOYSA-N
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
MeSH Unique ID
D017275
Source
PubChem CID 3784

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • Dynacirc
  • Isradipine, (+-)-Isomer
  • Isradipine, (R)-Isomer
  • Isradipine, (S)-Isomer
  • Lomir
  • PN 200-110
  • PN 205-033
  • PN 205-034
  • PN-200-110
  • PN-205-033
  • PN-205-034
  • PN 205 033
  • PN 205 034
  • PN 205033
  • PN 205034
  • PN205033
  • PN205034

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was ISRADIPINE (NM) 1983-92

MeSH Record

Previous Indexing

  • Dihydropyridines (1991-1992)
  • Oxadiazoles (1983-1991)
  • Pyridines (1987-1991)

MeSH Hierarchy

Tree Number

  1. D03w.383.725w.203.310w

AMA Style

References

  1. National Library of Medicine. Isradipine. Medical Subject Headings (MeSH). 2026. Unique ID D017275. http://id.nlm.nih.gov/mesh/2026/D017275
  2. Isradipine. In: Wikipedia. https://en.wikipedia.org/wiki/Isradipine
  3. Isradipine. In: Wikidata. https://www.wikidata.org/wiki/Q414873
  4. Isradipine. In: PubChem Compound. CID 3784. https://pubchem.ncbi.nlm.nih.gov/compound/3784