Structured Summary
Abstract
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Chemical Identity
Chemical Information
- Molecular Formula
- C35H38Cl2N8O4
- Molecular Weight
- 705.6 g/mol
- CAS Registry No.
- 84625-61-6
- IUPAC Name
- 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
- InChIKey
- VHVPQPYKVGDNFY-ZPGVKDDISA-N
- SMILES
- CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
- MeSH Unique ID
- D017964
- Source
- PubChem CID 55283
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
5 entry terms
- Orungal
- R-51211
- Sporanox
- R 51211
- R51211
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
94; was ITRACONAZOLE (NM) 1984-93
MeSH Record
Previous Indexing
- Ketoconazole/analogs & derivatives (1984-1993)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Itraconazole. Medical Subject Headings (MeSH). 2026. Unique ID D017964. http://id.nlm.nih.gov/mesh/2026/D017964
- Itraconazole. In: Wikipedia. https://en.wikipedia.org/wiki/Itraconazole
- Itraconazole. In: Wikidata. https://www.wikidata.org/wiki/Q411229
- Itraconazole. In: PubChem Compound. CID 55283. https://pubchem.ncbi.nlm.nih.gov/compound/55283