Chemicals and Drugs

Jumonji Domain-Containing Histone Demethylases

A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.

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Synonyms

3 entry terms
  • JmjC Domain-Containing Histone Demethylases
  • JmjC Domain Containing Histone Demethylases
  • Jumonji Domain Containing Histone Demethylases

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010

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Tree Numbers

  1. D08.811w.682w.662.582.475.500
  2. D08.811w.682w.690w.416w.388

AMA Style

References

  1. National Library of Medicine. Jumonji Domain-Containing Histone Demethylases. Medical Subject Headings (MeSH). 2026. Unique ID D056484. http://id.nlm.nih.gov/mesh/2026/D056484
  2. Jumonji Domain-Containing Histone Demethylases. In: Wikidata. https://www.wikidata.org/wiki/Q77922055