Chemicals and Drugs

Ketamine

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

Chemical Identity

Chemical Information

Molecular Formula
C13H16ClNO
Molecular Weight
237.72 g/mol
CAS Registry No.
6740-88-1
IUPAC Name
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
InChIKey
YQEZLKZALYSWHR-UHFFFAOYSA-N
SMILES
CNC1(CCCCC1=O)C2=CC=CC=C2Cl
MeSH Unique ID
D007649
Source
PubChem CID 3821

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
  • CI-581
  • Calipsol
  • Calypsol
  • Kalipsol
  • Ketalar
  • Ketamine Hydrochloride
  • Ketanest
  • Ketaset
  • CI 581
  • CI581

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

73; was CI-581 1969-72 (Prov)

MeSH Record

Previous Indexing

  • Analgesics (1966-1971)
  • Anesthetics (1972)
  • Cyclohexanes (1968-1972)

MeSH Hierarchy

Tree Number

  1. D02w.455w.426w.392.368w.367.652w

MeSH Record

NLM Classification

QV 81

AMA Style

References

  1. National Library of Medicine. Ketamine. Medical Subject Headings (MeSH). 2026. Unique ID D007649. http://id.nlm.nih.gov/mesh/2026/D007649
  2. Ketamine. In: Wikipedia. https://en.wikipedia.org/wiki/Ketamine
  3. Ketamine. In: Wikidata. https://www.wikidata.org/wiki/Q243547
  4. Ketamine. In: PubChem Compound. CID 3821. https://pubchem.ncbi.nlm.nih.gov/compound/3821