Structured Summary
Abstract
An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
12 entry terms
- Acetohydroxy Acid Isomeroreductase
- Alpha-Acetohydroxyacid Isomeroreductase
- Dihydroxyisovalerate Dehydrogenase (Isomerizing)
- Hydroxyacid Reductoisomerase
- Isomeroreductase
- Acid Isomeroreductase, Acetohydroxy
- Alpha Acetohydroxyacid Isomeroreductase
- Isomeroreductase, Acetohydroxy Acid
- Isomeroreductase, Alpha-Acetohydroxyacid
- Ketol Acid Reductoisomerase
- Reductoisomerase, Hydroxyacid
- Reductoisomerase, Ketol-Acid
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1980); use VALERATES 1970-1979
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Ketol-Acid Reductoisomerase. Medical Subject Headings (MeSH). 2026. Unique ID D050540. http://id.nlm.nih.gov/mesh/2026/D050540
- Ketol-Acid Reductoisomerase. In: Wikipedia. https://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase
- Ketol-Acid Reductoisomerase. In: Wikidata. https://www.wikidata.org/wiki/Q428209