Chemicals and Drugs

L-Type Calcium Channels

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

34 entry terms
  • Calcium Channels, L-Type
  • L-Type Calcium Channel
  • L-Type VDCC
  • L-Type Voltage-Dependent Calcium Channel
  • L-Type Voltage-Dependent Calcium Channels
  • Long-Lasting Calcium Channel
  • Long-Lasting Calcium Channels
  • Calcium Channel, L-Type
  • Calcium Channel, Long-Lasting
  • Calcium Channels, L Type
  • Calcium Channels, Long-Lasting
  • Channel, Long-Lasting Calcium
  • L Type Calcium Channel
  • L Type Calcium Channels
  • L Type VDCC
  • L Type Voltage Dependent Calcium Channel
  • L Type Voltage Dependent Calcium Channels
  • Long Lasting Calcium Channel
  • Long Lasting Calcium Channels
  • VDCC, L-Type
  • Dihydropyridine Receptor
  • Dihydropyridine Receptors
  • L-Type VDCC alpha-1 Subunit
  • L-Type VDCC alpha-2 Subunit
  • L-Type VDCC beta Subunit
  • L-Type VDCC delta Subunit
  • L-Type VDCC gamma Subunit
  • Receptors, Dihydropyridine
  • L Type VDCC alpha 1 Subunit
  • L Type VDCC alpha 2 Subunit
  • L Type VDCC beta Subunit
  • L Type VDCC delta Subunit
  • L Type VDCC gamma Subunit
  • Receptor, Dihydropyridine

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; use L-TYPE CALCIUM CHANNELS (NM) 1993-1999

MeSH Record

Previous Indexing

  • Calcium Channels (1993-1999)
  • Muscle Proteins (1993-1999)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.150w.400w
  2. D12.776w.543w.550w.450w.150w.400w
  3. D12.776w.543w.585w.400w.150w.400w

AMA Style

References

  1. National Library of Medicine. L-Type Calcium Channels. Medical Subject Headings (MeSH). 2026. Unique ID D020746. http://id.nlm.nih.gov/mesh/2026/D020746
  2. L-Type Calcium Channels. In: Wikipedia. https://en.wikipedia.org/wiki/L-type_calcium_channel
  3. L-Type Calcium Channels. In: Wikidata. https://www.wikidata.org/wiki/Q2600696