Structured Summary
Abstract
A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
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Synonyms
11 entry terms
- Lactase-Glycosylceramidase
- Hydrolase, Lactase-Phlorizin
- Lactase Glycosylceramidase
- Lactase Phlorizin Hydrolase
- Glycosyl Ceramidase
- Glycosylceramidase
- Phloretin-Glucosidase
- Phlorizin Hydrolase
- Ceramidase, Glycosyl
- Hydrolase, Phlorizin
- Phloretin Glucosidase
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2014 (1992)
MeSH Record
Previous Indexing
- Glucosidases (1966-1977)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Lactase-Phlorizin Hydrolase. Medical Subject Headings (MeSH). 2026. Unique ID D010694. http://id.nlm.nih.gov/mesh/2026/D010694
- Lactase-Phlorizin Hydrolase. In: Wikidata. https://www.wikidata.org/wiki/Q76604132