Diseases

Lafora Disease

A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

17 entry terms
  • Epilepsy Progressive Myoclonic 2
  • Epilepsy, Progressive Myoclonic 2A
  • Epilepsy, Progressive Myoclonic, Lafora
  • Lafora Body Disease
  • Lafora Body Disorder
  • Lafora Progressive Myoclonic Epilepsy
  • Lafora Progressive Myoclonus Epilepsy
  • Lafora Type Progressive Myoclonic Epilepsy
  • Myoclonic Epilepsy of Lafora
  • Progressive Myoclonic Epilepsy Type 2
  • Progressive Myoclonic Epilepsy, Lafora
  • Progressive Myoclonic Epilepsy, Lafora Type
  • Progressive Myoclonus Epilepsy, Lafora Type
  • Lafora Myoclonic Epilepsy
  • Lafora Body Disease, Late Onset
  • Lafora-Body Disease, Late Onset
  • Late Onset Lafora Body Disease

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2000; use Epilepsy, Myoclonic 1977-1999

MeSH Record

Previous Indexing

  • Epilepsies, Myoclonic (1977-1999)
  • Epilepsy (1966-1976)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.490w.375w.130w.650w.500w
  2. C10w.228w.140w.490w.493w.063w.650w.500w
  3. C10w.574w.500.529w
  4. C16w.320w.400.480w

AMA Style

References

  1. National Library of Medicine. Lafora Disease. Medical Subject Headings (MeSH). 2026. Unique ID D020192. http://id.nlm.nih.gov/mesh/2026/D020192
  2. Lafora Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Lafora_disease
  3. Lafora Disease. In: Wikidata. https://www.wikidata.org/wiki/Q163905