Diseases

Langer-Giedion Syndrome

Autosomal dominant disorder characterized by cone-shaped epiphyses in the hands and multiple cartilaginous exostoses. INTELLECTUAL DISABILITY and abnormalities of chromosome 8 are often present. The exostoses in this syndrome appear identical to those of hereditary multiple exostoses (EXOSTOSES, HEREDITARY MULTIPLE).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Autosomal dominant disorder characterized by cone-shaped epiphyses in the hands and multiple cartilaginous exostoses. INTELLECTUAL DISABILITY and abnormalities of chromosome 8 are often present. The exostoses in this syndrome appear identical to those of hereditary multiple exostoses (EXOSTOSES, HEREDITARY MULTIPLE).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

14 entry terms
  • Acrodysplasia V
  • Giedion-Langer Syndrome
  • TRPSII
  • Tricho-Rhino-Phalangeal Syndrome Type II
  • Trichorhinophalangeal Syndrome Type 2
  • Trichorhinophalangeal Syndrome Type II
  • Trichorhinophalangeal Syndrome with Exostoses
  • Trichorhinophalangeal Syndrome, Type II
  • Acrodysplasia Vs
  • Giedion Langer Syndrome
  • Langer Giedion Syndrome
  • Syndrome, Giedion-Langer
  • Syndrome, Langer-Giedion
  • Tricho Rhino Phalangeal Syndrome Type II

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

an osteochondrodysplasia

MeSH Record

History Note

90; was GIEDION-LANGER SYNDROME see EXOSTOSES, MULTIPLE 1968-89

MeSH Record

Previous Indexing

  • Exostoses, Multiple (1972-1989)

MeSH Hierarchy

Tree Number

  1. C05w.116w.099.708w.582w

AMA Style

References

  1. National Library of Medicine. Langer-Giedion Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D015826. http://id.nlm.nih.gov/mesh/2026/D015826
  2. Langer-Giedion Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Langer%E2%80%93Giedion_syndrome
  3. Langer-Giedion Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q3508795