Chemicals and Drugs

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • Dardarin Protein
  • LRRK2 Protein
  • PARK8 Protein
  • Leucine Rich Repeat Serine Threonine Protein Kinase 2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Protein-Serine-Threonine Kinases (2005-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.534
  2. D12.776w.476.563w.534
  3. D12.776w.705.750

AMA Style

References

  1. National Library of Medicine. Leucine-Rich Repeat Serine-Threonine Protein Kinase-2. Medical Subject Headings (MeSH). 2026. Unique ID D000071158. http://id.nlm.nih.gov/mesh/2026/D000071158
  2. Leucine-Rich Repeat Serine-Threonine Protein Kinase-2. In: Wikidata. https://www.wikidata.org/wiki/Q21146388