Structured Summary
Abstract
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
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Classification
Broader headings
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MeSH Record
Synonyms
12 entry terms
- Cytosol Aminopeptidase
- L-Leucylnaphthylamidase
- Leucine Aminopeptidase
- Peptidase S
- Zinc-Manganese-Leucine Aminopeptidase
- Aminopeptidase, Cytosol
- Aminopeptidase, Leucine
- Aminopeptidase, Leucyl
- Aminopeptidase, Zinc-Manganese-Leucine
- Zinc Manganese Leucine Aminopeptidase
- Methoxyleucine Aminopeptidase
- Aminopeptidase, Methoxyleucine
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
1999(1965)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Leucyl Aminopeptidase. Medical Subject Headings (MeSH). 2026. Unique ID D007931. http://id.nlm.nih.gov/mesh/2026/D007931
- Leucyl Aminopeptidase. In: Wikipedia. https://en.wikipedia.org/wiki/Leucyl_aminopeptidase
- Leucyl Aminopeptidase. In: Wikidata. https://www.wikidata.org/wiki/Q907220