Chemicals and Drugs

Levamisole

An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)

Chemical Identity

Chemical Information

Molecular Formula
C11H12N2S
Molecular Weight
204.29 g/mol
CAS Registry No.
14769-73-4
IUPAC Name
(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
InChIKey
HLFSDGLLUJUHTE-SNVBAGLBSA-N
SMILES
C1CSC2=N[C@H](CN21)C3=CC=CC=C3
MeSH Unique ID
D007978
Source
PubChem CID 26879

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • L-Tetramisole
  • Levotetramisole
  • Decaris
  • Dekaris
  • Levamisole Hydrochloride
  • Solaskil
  • Hydrochloride, Levamisole

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

74

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.675.346w
  2. D03w.383.129w.308.480w
  3. D03w.383.129w.708.346w

AMA Style

References

  1. National Library of Medicine. Levamisole. Medical Subject Headings (MeSH). 2026. Unique ID D007978. http://id.nlm.nih.gov/mesh/2026/D007978
  2. Levamisole. In: Wikipedia. https://en.wikipedia.org/wiki/Levamisole
  3. Levamisole. In: Wikidata. https://www.wikidata.org/wiki/Q417097
  4. Levamisole. In: PubChem Compound. CID 26879. https://pubchem.ncbi.nlm.nih.gov/compound/26879