Chemicals and Drugs

Linagliptin

A purine and quinazoline derivative that functions as an INCRETIN and DIPEPTIDYL-PEPTIDASE IV INHIBTOR. It is used as a HYPOGLYCEMIC AGENT in the treatment of TYPE II DIABETES MELLITUS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A purine and quinazoline derivative that functions as an INCRETIN and DIPEPTIDYL-PEPTIDASE IV INHIBTOR. It is used as a HYPOGLYCEMIC AGENT in the treatment of TYPE II DIABETES MELLITUS.

Chemical Identity

Chemical Information

Molecular Formula
C25H28N8O2
Molecular Weight
472.5 g/mol
CAS Registry No.
668270-12-0
IUPAC Name
8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
InChIKey
LTXREWYXXSTFRX-QGZVFWFLSA-N
SMILES
CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C
MeSH Unique ID
D000069476
Source
PubChem CID 10096344

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
  • 1H-purine-2,6-dione, 8-((3r)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)-
  • BI 1356
  • BI-1356
  • BI1356
  • Tradjenta
  • Trajenta
  • 1356, BI

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2011)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.562w
  2. D03w.633.100.786.563w

AMA Style

References

  1. National Library of Medicine. Linagliptin. Medical Subject Headings (MeSH). 2026. Unique ID D000069476. http://id.nlm.nih.gov/mesh/2026/D000069476
  2. Linagliptin. In: Wikipedia. https://en.wikipedia.org/wiki/Linagliptin
  3. Linagliptin. In: Wikidata. https://www.wikidata.org/wiki/Q909745
  4. Linagliptin. In: PubChem Compound. CID 10096344. https://pubchem.ncbi.nlm.nih.gov/compound/10096344