Diseases

Locked-In Syndrome

Acquired neuromuscular disorder characterized by complete paralysis of voluntary muscles and lower CRANIAL NERVES except for limited voluntary eye movements. It is due to various cerebrospinal disconnections at or near the PONS and the POSTERIOR CRANIAL FOSSA, typically secondary to pontine hemorrhage or infarct. Because cognitive function is intact it is sometimes referred to as a pseudocoma state.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Acquired neuromuscular disorder characterized by complete paralysis of voluntary muscles and lower CRANIAL NERVES except for limited voluntary eye movements. It is due to various cerebrospinal disconnections at or near the PONS and the POSTERIOR CRANIAL FOSSA, typically secondary to pontine hemorrhage or infarct. Because cognitive function is intact it is sometimes referred to as a pseudocoma state.

MeSH Record

Classification

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MeSH Record

Synonyms

6 entry terms
  • Cerebromedullospinal Disconnection
  • Ventral Pontine Syndrome
  • Cerebromedullospinal Disconnections
  • Locked In Syndrome
  • Locked-In Syndromes
  • Ventral Pontine Syndromes

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2020(1981)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Locked-In Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D000080422. http://id.nlm.nih.gov/mesh/2026/D000080422
  2. Locked-In Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Locked-in_syndrome
  3. Locked-In Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q794457