Chemicals and Drugs

Loperamide

One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

Chemical Identity

Chemical Information

Molecular Formula
C29H33ClN2O2
Molecular Weight
477.0 g/mol
CAS Registry No.
53179-11-6
IUPAC Name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
InChIKey
RDOIQAHITMMDAJ-UHFFFAOYSA-N
SMILES
CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
MeSH Unique ID
D008139
Source
PubChem CID 3955

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • Imodium
  • Loperamide Hydrochloride
  • Loperamide Monohydrochloride
  • R-18553
  • Hydrochloride, Loperamide
  • Monohydrochloride, Loperamide
  • R 18553
  • R18553

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(76); was see under PIPERIDINES 1976-90

MeSH Record

Previous Indexing

  • Amides (1974-1975)
  • Chlorobenzenes (1974-1975)
  • Piperidines (1974-1975)

MeSH Hierarchy

Tree Number

  1. D03w.383.621.440w

MeSH Record

NLM Classification

QV 71

AMA Style

References

  1. National Library of Medicine. Loperamide. Medical Subject Headings (MeSH). 2026. Unique ID D008139. http://id.nlm.nih.gov/mesh/2026/D008139
  2. Loperamide. In: Wikipedia. https://en.wikipedia.org/wiki/Loperamide
  3. Loperamide. In: Wikidata. https://www.wikidata.org/wiki/Q423751
  4. Loperamide. In: PubChem Compound. CID 3955. https://pubchem.ncbi.nlm.nih.gov/compound/3955