Structured Summary
Abstract
A monochloroacetyl derivative of ajmaline. It is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.
Chemical Identity
Chemical Information
- Molecular Formula
- C22H27ClN2O3
- Molecular Weight
- 402.9 g/mol
- CAS Registry No.
- 47562-08-3
- IUPAC Name
- [(1R,9R,10S,12R,13S,14R,16S,17S,18R)-13-ethyl-14-hydroxy-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-trien-18-yl] 2-chloroacetate
- InChIKey
- LAHDERDHXJFFJU-ZWNKPRIXSA-N
- SMILES
- CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H]([C@H]2[C@H]5OC(=O)CCl)N3[C@@H]1O)C6=CC=CC=C6N4C
- MeSH Unique ID
- D064794
- Source
- PubChem CID 76957773
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
2 entry terms
- Lorajmine Hydrochloride
- Hydrochloride, Lorajmine
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2014; use AJMALINE 1973-2013
MeSH Record
Previous Indexing
- Ajmaline (1973-2013)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Lorajmine. Medical Subject Headings (MeSH). 2026. Unique ID D064794. http://id.nlm.nih.gov/mesh/2026/D064794
- Lorajmine. In: Wikipedia. https://en.wikipedia.org/wiki/Lorajmine
- Lorajmine. In: Wikidata. https://www.wikidata.org/wiki/Q6678756
- Lorajmine. In: PubChem Compound. CID 76957773. https://pubchem.ncbi.nlm.nih.gov/compound/76957773