Chemicals and Drugs

Losartan

An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.

Chemical Identity

Chemical Information

Molecular Formula
C22H23ClN6O
Molecular Weight
422.9 g/mol
CAS Registry No.
114798-26-4
IUPAC Name
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
InChIKey
PSIFNNKUMBGKDQ-UHFFFAOYSA-N
SMILES
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
MeSH Unique ID
D019808
Source
PubChem CID 3961

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

13 entry terms
  • 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
  • Cozaar
  • DuP-753
  • Losartan Monopotassium Salt
  • Losartan Potassium
  • MK-954
  • MK954
  • DuP 753
  • DuP753
  • MK 954
  • Monopotassium Salt, Losartan
  • Potassium, Losartan
  • Salt, Losartan Monopotassium

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use LOSARTAN (NM) 1990-97

MeSH Record

Previous Indexing

  • Biphenyl Compounds (1990-1997)
  • Imidazoles (1990-1997)
  • Tetrazoles (1990-1997)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.389.185.475w
  2. D03w.383.129w.308.507w
  3. D03w.383.129w.617.467w

AMA Style

References

  1. National Library of Medicine. Losartan. Medical Subject Headings (MeSH). 2026. Unique ID D019808. http://id.nlm.nih.gov/mesh/2026/D019808
  2. Losartan. In: Wikipedia. https://en.wikipedia.org/wiki/Losartan
  3. Losartan. In: Wikidata. https://www.wikidata.org/wiki/Q410074
  4. Losartan. In: PubChem Compound. CID 3961. https://pubchem.ncbi.nlm.nih.gov/compound/3961