Phenomena and Processes

Loss of Heterozygosity

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

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Synonyms

4 entry terms
  • Allelic Loss
  • Heterozygosity, Loss of
  • Allelic Losses
  • Heterozygosity Loss

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Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

do not confuse entry term ALLELIC LOSS with ALLELIC IMBALANCE

MeSH Record

History Note

98

MeSH Record

Previous Indexing

  • Chromosome Deletion (1987-1997)
  • Heterozygote (1983-1997)

MeSH Hierarchy

Tree Number

  1. G05.365w.590w.029.530w

AMA Style

References

  1. National Library of Medicine. Loss of Heterozygosity. Medical Subject Headings (MeSH). 2026. Unique ID D019656. http://id.nlm.nih.gov/mesh/2026/D019656
  2. Loss of Heterozygosity. In: Wikipedia. https://en.wikipedia.org/wiki/Loss_of_heterozygosity
  3. Loss of Heterozygosity. In: Wikidata. https://www.wikidata.org/wiki/Q2617554