Chemicals and Drugs

Lupus Coagulation Inhibitor

An antiphospholipid antibody found in association with a variety of diseases (e.g., SYSTEMIC LUPUS ERYTHEMATOSUS and ANTIPHOSPHOLIPID SYNDROME) as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antiphospholipid antibody found in association with a variety of diseases (e.g., SYSTEMIC LUPUS ERYTHEMATOSUS and ANTIPHOSPHOLIPID SYNDROME) as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • Anticoagulant, Lupus
  • Coagulation Inhibitor, Lupus
  • Inhibitor, Lupus Coagulation
  • Lupus Anticoagulant
  • Lupus Anticoagulant Autoantibodies
  • Lupus Anticoagulant Autoantibody
  • Anticoagulant Autoantibody, Lupus
  • Autoantibody, Lupus Anticoagulant

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

92; was LUPUS COAGULATION INHIBITOR (NM) 1978-91

MeSH Record

Previous Indexing

  • Autoantibodies (1966-1991)
  • Blood Coagulation Factors (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.323w.210.600w
  2. D12.776w.124w.790.651.114w.323w.210.600w
  3. D12.776w.377w.715.548.114w.323w.210.600w
  4. D23.113.475w

AMA Style

References

  1. National Library of Medicine. Lupus Coagulation Inhibitor. Medical Subject Headings (MeSH). 2026. Unique ID D016682. http://id.nlm.nih.gov/mesh/2026/D016682
  2. Lupus Coagulation Inhibitor. In: Wikipedia. https://en.wikipedia.org/wiki/Lupus_anticoagulant
  3. Lupus Coagulation Inhibitor. In: Wikidata. https://www.wikidata.org/wiki/Q5786759