Structured Summary
Abstract
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
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Classification
Broader headings
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Synonyms
12 entry terms
- Protein Tyrosine Kinase p56(lck)
- Proto-Oncogene Protein c-lck
- Proto-Oncogene Protein lck
- lck Kinase
- p56 lck
- Kinase, lck
- Protein c-lck, Proto-Oncogene
- Protein lck, Proto-Oncogene
- Proto Oncogene Protein c lck
- Proto Oncogene Protein lck
- c-lck, Proto-Oncogene Protein
- lck, Proto-Oncogene Protein
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
98; use LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK) (NM) 1988-97
MeSH Record
Previous Indexing
- Protein-Tyrosine Kinase (1988-1995)
- src-Family Kinases (1996-1997)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Lymphocyte Specific Protein Tyrosine Kinase p56(lck). Medical Subject Headings (MeSH). 2026. Unique ID D019860. http://id.nlm.nih.gov/mesh/2026/D019860
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck). In: Wikidata. https://www.wikidata.org/wiki/Q9020944