Anatomy

Lymphokine-Activated Killer Cells

Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.

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Classification

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See Also

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Synonyms

11 entry terms
  • Killer Cells, Lymphokine-Activated
  • LAK Cells
  • Cell, LAK
  • Cell, Lymphokine-Activated Killer
  • Cells, LAK
  • Cells, Lymphokine-Activated Killer
  • Killer Cell, Lymphokine-Activated
  • Killer Cells, Lymphokine Activated
  • LAK Cell
  • Lymphokine Activated Killer Cells
  • Lymphokine-Activated Killer Cell

MeSH Record

Aspects Covered

15 allowable subheadings

Indexed with the subheadings chemistry, classification, cytology, drug effects, enzymology, immunology, metabolism, microbiology, parasitology, pathology, physiology, radiation effects, transplantation, ultrastructure, virology.

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Indexing Annotation

if subpopulations are discussed, coordinate IM with LYMPHOCYTE SUBSETS (IM)

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Killer Cells, Natural (1982-1989)

MeSH Hierarchy

Tree Numbers

  1. A11w.118w.637w.555w.283w.500w
  2. A11w.118w.637w.555w.567w.537w.500w
  3. A15.145w.229w.637w.555w.283w.500w
  4. A15.145w.229w.637w.555w.567w.537w.500w
  5. A15.382w.490w.555w.283w.500w
  6. A15.382w.490w.555w.567w.537w.500w

AMA Style

References

  1. National Library of Medicine. Lymphokine-Activated Killer Cells. Medical Subject Headings (MeSH). 2026. Unique ID D015979. http://id.nlm.nih.gov/mesh/2026/D015979
  2. Lymphokine-Activated Killer Cells. In: Wikipedia. https://en.wikipedia.org/wiki/Lymphokine-activated_killer_cell
  3. Lymphokine-Activated Killer Cells. In: Wikidata. https://www.wikidata.org/wiki/Q4259786