Chemicals and Drugs

Lysergic Acid Diethylamide

Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.

Chemical Identity

Chemical Information

Molecular Formula
C20H25N3O
Molecular Weight
323.4 g/mol
CAS Registry No.
50-37-3
IUPAC Name
(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
InChIKey
VAYOSLLFUXYJDT-RDTXWAMCSA-N
SMILES
CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C
MeSH Unique ID
D008238
Source
PubChem CID 5761

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • LSD
  • LSD-25
  • Lysergide
  • Acid Diethylamide, Lysergic
  • Diethylamide, Lysergic Acid
  • LSD 25
  • Lysergic Acid Diethylamide Tartrate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.327.287.572w.522w
  2. D03w.633.400.439.572w.522w

MeSH Record

NLM Classification

QV 77.7

AMA Style

References

  1. National Library of Medicine. Lysergic Acid Diethylamide. Medical Subject Headings (MeSH). 2026. Unique ID D008238. http://id.nlm.nih.gov/mesh/2026/D008238
  2. Lysergic Acid Diethylamide. In: Wikipedia. https://en.wikipedia.org/wiki/LSD
  3. Lysergic Acid Diethylamide. In: Wikidata. https://www.wikidata.org/wiki/Q23118
  4. Lysergic Acid Diethylamide. In: PubChem Compound. CID 5761. https://pubchem.ncbi.nlm.nih.gov/compound/5761