Structured Summary
Abstract
A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
4 entry terms
- AlkB Homolog 4, Lysine Demethylase
- Alkylated DNA Repair Protein AlkB Homolog 4
- Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
- Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Dioxygenases (2014-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Lysine Demethylase AlkB Homolog 4. Medical Subject Headings (MeSH). 2026. Unique ID D000071501. http://id.nlm.nih.gov/mesh/2026/D000071501
- Lysine Demethylase AlkB Homolog 4. In: Wikidata. https://www.wikidata.org/wiki/Q21111334