Chemicals and Drugs

MRE11 Homologue Protein

A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • MRE11A Protein
  • Meiotic Recombination 11 Homolog 1 Protein
  • Homologue Protein, MRE11

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • DNA-Binding Proteins (1999-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.335w.350w.650
  2. D08.811w.277w.352w.335w.375w.813
  3. D08.811w.277w.352w.355w.325w.600
  4. D08.811w.277w.352w.365w.290w.250
  5. D12.776w.157w.687.495
  6. D12.776w.260w.539
  7. D12.776w.660w.720.495

AMA Style

References

  1. National Library of Medicine. MRE11 Homologue Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000076228. http://id.nlm.nih.gov/mesh/2026/D000076228
  2. MRE11 Homologue Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24780635