Chemicals and Drugs

Macrophage Colony-Stimulating Factor

A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

7 entry terms
  • CSF-1
  • CSF-M
  • Colony-Stimulating Factor 1
  • Colony-Stimulating Factor, Macrophage
  • M-CSF
  • Colony Stimulating Factor 1
  • Colony Stimulating Factor, Macrophage

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Colony-Stimulating Factors (1976-1990)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.775w.500
  2. D12.644w.276.374w.410.240w.500
  3. D12.776w.395w.240w.500
  4. D12.776w.467.374w.410.240w.500
  5. D23.529.374w.410.240w.500

AMA Style

References

  1. National Library of Medicine. Macrophage Colony-Stimulating Factor. Medical Subject Headings (MeSH). 2026. Unique ID D016173. http://id.nlm.nih.gov/mesh/2026/D016173
  2. Macrophage Colony-Stimulating Factor. In: Wikidata. https://www.wikidata.org/wiki/Q24773247