Chemicals and Drugs

Mad2 Proteins

Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Mad2 Mitotic Arrest Deficient-like 1 Proteins

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Hierarchy

Tree Numbers

  1. D12.776w.167.313
  2. D12.776w.660w.526

AMA Style

References

  1. National Library of Medicine. Mad2 Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D064246. http://id.nlm.nih.gov/mesh/2026/D064246
  2. Mad2 Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q76743905