Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Mass Matrix-Assisted Laser Desorption-Ionization Spectrometry

A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.

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Synonyms

17 entry terms
  • Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
  • MALD-MS
  • MALDI
  • MALDI-MS
  • MS-MALD
  • Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
  • Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
  • Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Laser Desorption Ionization Mass Spectrometry, Matrix Assisted
  • MALDI MS
  • Mass Spectrometry, Matrix Assisted Laser Desorption Ionization
  • Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization
  • Matrix Assisted Laser Desorption Ionization Mass Spectrometry
  • SELDI-TOF-MS
  • Surface Enhanced Laser Desorption Ionization Mass Spectrometry

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Aspects Covered

10 allowable subheadings

Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.

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History Note

96

MeSH Record

Previous Indexing

  • Spectrum Analysis, Mass (1989-1995)

MeSH Hierarchy

Tree Number

  1. E05.196w.566w.755w

AMA Style

References

  1. National Library of Medicine. Mass Matrix-Assisted Laser Desorption-Ionization Spectrometry. Medical Subject Headings (MeSH). 2026. Unique ID D019032. http://id.nlm.nih.gov/mesh/2026/D019032
  2. Mass Matrix-Assisted Laser Desorption-Ionization Spectrometry. In: Wikipedia. https://en.wikipedia.org/wiki/Matrix-assisted_laser_desorption/ionization
  3. Mass Matrix-Assisted Laser Desorption-Ionization Spectrometry. In: Wikidata. https://www.wikidata.org/wiki/Q736400