Diseases

Mast Cell Activation Disorders

A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. These disorders are associated with various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other genes, underlying conditions, and responses to allergic or non-allergic triggers of mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics, muscle relaxants, specific foods, environmental toxins, physical conditions such as vibration, cold, pressure, and stress.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. These disorders are associated with various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other genes, underlying conditions, and responses to allergic or non-allergic triggers of mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics, muscle relaxants, specific foods, environmental toxins, physical conditions such as vibration, cold, pressure, and stress.

MeSH Record

Classification

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MeSH Record

Synonyms

8 entry terms
  • Mast Cell Activation Disease
  • Mast Cell Disease
  • Mast-Cell Disease
  • Mast Cell Diseases
  • Mast-Cell Diseases
  • Clonal Mast Cell Proliferation Disorders
  • Monoclonal Mast Cell Activation Syndrome
  • Primary Mast Cell Activation Disorders

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2022; for MAST CELL ACTIVATION DISEASE use MASTOCYTOSIS 2018-2021

MeSH Hierarchy

Tree Number

  1. C20w.762

AMA Style

References

  1. National Library of Medicine. Mast Cell Activation Disorders. Medical Subject Headings (MeSH). 2026. Unique ID D000090362. http://id.nlm.nih.gov/mesh/2026/D000090362
  2. Mast Cell Activation Disorders. In: Wikidata. https://www.wikidata.org/wiki/Q112125389