Chemicals and Drugs

Mefloquine

A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.

Chemical Identity

Chemical Information

Molecular Formula
C17H16F6N2O
Molecular Weight
378.31 g/mol
CAS Registry No.
53230-10-7
IUPAC Name
[2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol
InChIKey
XEEQGYMUWCZPDN-UHFFFAOYSA-N
SMILES
C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
MeSH Unique ID
D015767
Source
PubChem CID 4046

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Mephloquine
  • Lariam
  • Mefloquine Hydrochloride
  • Ro-21-5998-001
  • WR-142,490
  • WR-177,602
  • Ro 21 5998 001
  • Ro215998001
  • WR 142,490
  • WR 177,602
  • WR142,490
  • WR177,602

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Antimalarials (1966-1989)
  • Quinolines (1966-1989)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Mefloquine. Medical Subject Headings (MeSH). 2026. Unique ID D015767. http://id.nlm.nih.gov/mesh/2026/D015767
  2. Mefloquine. In: Wikipedia. https://en.wikipedia.org/wiki/Mefloquine
  3. Mefloquine. In: Wikidata. https://www.wikidata.org/wiki/Q736270
  4. Mefloquine. In: PubChem Compound. CID 4046. https://pubchem.ncbi.nlm.nih.gov/compound/4046