Chemicals and Drugs

Megestrol Acetate

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Chemical Identity

Chemical Information

Molecular Formula
C24H32O4
Molecular Weight
384.5 g/mol
CAS Registry No.
595-33-5
IUPAC Name
[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
InChIKey
RQZAXGRLVPAYTJ-GQFGMJRRSA-N
SMILES
CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
MeSH Unique ID
D019290
Source
PubChem CID 11683

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • Acetate, Megestrol
  • Apo-Megestrol
  • Borea
  • Lin-Megestrol
  • Maygace
  • Megace
  • Megefren
  • Megestat
  • Megostat
  • Mestrel
  • Nu-Megestrol
  • Apo Megestrol
  • ApoMegestrol
  • Lin Megestrol
  • LinMegestrol
  • Nu Megestrol
  • NuMegestrol

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

97;

MeSH Record

Previous Indexing

  • Megestrol/analogs & derivatives (1980-1996)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.745.432w.531w.500w

AMA Style

References

  1. National Library of Medicine. Megestrol Acetate. Medical Subject Headings (MeSH). 2026. Unique ID D019290. http://id.nlm.nih.gov/mesh/2026/D019290
  2. Megestrol Acetate. In: Wikipedia. https://en.wikipedia.org/wiki/Megestrol_acetate
  3. Megestrol Acetate. In: Wikidata. https://www.wikidata.org/wiki/Q6808975
  4. Megestrol Acetate. In: PubChem Compound. CID 11683. https://pubchem.ncbi.nlm.nih.gov/compound/11683