Chemicals and Drugs

Meglutol

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

Chemical Identity

Chemical Information

Molecular Formula
C6H10O5
Molecular Weight
162.14 g/mol
CAS Registry No.
503-49-1
IUPAC Name
3-hydroxy-3-methylpentanedioic acid
InChIKey
NPOAOTPXWNWTSH-UHFFFAOYSA-N
SMILES
CC(CC(=O)O)(CC(=O)O)O
MeSH Unique ID
D015093
Source
PubChem CID 1662

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • 3-Hydroxy-3-methylglutaric Acid
  • 3-Hydroxy-3-methylpentanedioic Acid
  • beta-Hydroxy-beta-Methylglutarate
  • 3 Hydroxy 3 methylglutaric Acid
  • 3 Hydroxy 3 methylpentanedioic Acid
  • Acid, 3-Hydroxy-3-methylglutaric
  • Acid, 3-Hydroxy-3-methylpentanedioic
  • beta Hydroxy beta Methylglutarate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)

MeSH Record

Previous Indexing

  • Anticholesteremic Agents (1966-1979)
  • Antilipemic Agents (1966-1972)
  • Glutarates (1966-1979)
  • Hydroxy Acids (1975-1979)

MeSH Hierarchy

Tree Number

  1. D02w.241w.081.337w.351.550w

AMA Style

References

  1. National Library of Medicine. Meglutol. Medical Subject Headings (MeSH). 2026. Unique ID D015093. http://id.nlm.nih.gov/mesh/2026/D015093
  2. Meglutol. In: Wikipedia. https://en.wikipedia.org/wiki/Meglutol
  3. Meglutol. In: Wikidata. https://www.wikidata.org/wiki/Q524670
  4. Meglutol. In: PubChem Compound. CID 1662. https://pubchem.ncbi.nlm.nih.gov/compound/1662